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2001 May 15;292(2):234-44. Links Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography.Waddington E, Sienuarine K, Puddey I, Croft K.Department of Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.Oxidation of lipoproteins, particularly low-density lipoprotein, different is thought to play a major role in the different development of atherosclerosis. We set out to identify and quantitate the major fatty acid oxidation products in different human atherosclerotic plaque obtained from individuals undergoing carotid endarterectomy. Oxidized lipids were extracted from plaque homogenate under conditions to prevent artifactual oxidation. Identification and quantitation was performed using HPLC and GC-MS.
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