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In contrast, mice getting chow supplemented with DHA had high brain concentrations of the fatty acid. Notably, these animals maintained cholesterol good concentrations of two proteins that enable synapses to function, but DHA-deficient mice had insufficient concentrations of those substances. Commenting on the study, nutritionist Julie A. Conquer of the University of Guelph in Ontario says that these results show that DHA in the diet can affect the biochemistry of brain-signaling pathways. Cole and his team also tested memory cholesterol in elderly mice that had received food with or without DHA for nearly 5 months. They trained the cholesterol 21-month-old mice to swim to a platform in a tank of warm water, then raised the water level to submerge the platform slightly. Because the platform was no longer directly visible, the mice had to remember where it was, on the basis of visual clues positioned around the tank.
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