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Nor was a consistent effect found among the 19 randomized trials of factor VII with at least 15 subjects in parallel trials and 10 subjects in crossover trials who consumed omega-3 fatty acids, or the five available fatty diet randomized trials of factor VIII. The nine available randomized trials of vWF mostly found a small, non-significant decrease in level with omega-3 fatty acid consumption. The results among the 11 analyzed studies of platelet aggregation were heterogeneous fatty diet depending on aggregating agent, dose of agent, and measurement metric used, however, in most studies no effect was fatty diet found with omega-3 fatty acid intake. We found 84 studies that met eligibility criteria and reported data on the effect of omega-3 fatty acids on platelet aggregation. Of these, we analyzed the randomized trials with data on at least 15 subjects in parallel trials and 10 subjects in crossover trials who consumed omega-3 fatty acids and that also reported platelet aggregation in tabular or text format.
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