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Ratios that are higher than the normal mean are designated with an "H" ratios lower are designated with health & fitness an "L". Normal ranges health & fitness are provided for plasma, urine and CSF. Note: normal ranges health & fitness vary with age: please include date of birth to ensure correct table is used for interpretation. Brief clinical history is also required for adequate interpretation. E. Limitations of procedure Although many metabolic disorders are the result of enzyme deficiencies in the metabolism of specific amino acids, a significant elevation of the specific amino acids may not always occur. Organic acid analysis is recommended in those cases where the suspected enzyme deficiency is more than one step removed from the parent amino acid on the biochemical pathway. In well managed patients, the amino acid levels can be within normal limits. Amino acid analysis is useful for monitoring the management of several metabolic disorders such as MSUD, PKU and the urea cycle defects where certain dietary restrictions are required.
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