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plump mom , phytochemicals, fat girls having sex , instruments, microbial identification, health & fitness / diets, time: current, biochemistry, fat bottom girls , busty plump , fatty knees , metrohm, ezcema, firms, psoriasis, plump pics , nutrition, content, food testing, plump up , emu ranching, omega 3 and omega 6 fatty acids , science, | Primrose oil was chosen because it contains 9% gamma linolenic acid (GLA. 18:3 n6), the product of delta-6 desaturation of LA. In a double-blind study using three levels of primrose oil (2.0. 4.0, and 6.0 gm daily) they found emus a significant, dose-dependent reduction in inflammation determined by pruritus, erythema, and scaling. emus EFA levels showed significant improvement as well [24]. This suggested that the intake of GLA was exerting not only a corrective effect on the usual skin signs of EFA deficiency. but an antiinflammatory and immunomodulatory effect. The investigators postulated that D6DH impairment in this group of atopic patients, with its resulting decrease in the levels of PG precursors, was impairing the synthesis of immunoregulatory prostaglandins [23]. |
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One of these metabolites, eicosapentaenoic psoriasis acid (EPA; 20:5 n3), is a precursor of the trienoic PGs. Small amounts of EPA may have significant effects on PG production in vivo [25]. EPA is a potent competitive inhibitor of AA for PG synthetase and for the lipoxygenase that initiates LT synthesis [26-28]. Whereas some tissues. such as liver [29] and brain [30], possess a full complement of enzymes for PUFA synthesis, others, such psoriasis as skin [31], granulocytes [32], and platelets [33], lack D6DH. They must extract 20-carbon EFAs for PG synthesis from plasma, an important transport psoriasis step catalyzed by a specific arachidonoyl-CoA synthetase [33]. EPA is a potent inhibitor of AA transport into these cells. The n3 EFAs, therefore, exert multiple regulatory effects on n6 metabolism. English investigators administered evening primrose oil (EPO) as a dietary supplement to patients whose EFA levels they studied [34]. |
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