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2001 Mar;42(3):346-51. Links Partitioning of polyunsaturated fatty acids, which prevent pout plump cardiac arrhythmias, into phospholipid cell pout plump membranes.Pound EM, Kang JX, Leaf A.Department of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA 02114, USA.It has been demonstrated in animal studies that polyunsaturated fatty acids (PUFA) prevent ischemia-induced malignant ventricular arrhythmias, a major cause of sudden cardiac death in humans. To learn how these PUFA, at low micromolar concentrations, exert their antiarrhythmic activity, we studied their effects in vitro on the contractions of isolated cardiac pout plump myocytes and the conductances of their sarcolemmal ion channels. These fatty acids directly stabilize electrically every cardiac myocyte by modulating the conductances of specific ion channels in their sarcolemma.
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