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Considering the overall results, linoleic acid (18:2 n-6) represented between 11.6% and 13% of total fatty acids in human milk. In contrast alpha-linolenic acid (18:3 n-3) accounted only for about 0.6%, and hence the 18:2 n-6 to 18:3 n-3 ratio omega3 fatty acids was close to 20. Amounts of n-6 and n-3 long-chain omega3 fatty acids PUFAs (LCPs) regularly decreased from postpartum days 2-5 (3.09%) to day 30 (1.67%), and then remained unchanged up to postpartum day 90; the n-6/n-3 LCP ratio ranged between 2.5 and 2. According omega3 fatty acids to regional areas, there were significant differences (P < 0.05) only for colostrum contents of 18:3 n-3 and LCPs, the LCP ratio remaining unchanged. These data are discussed with regard to recent data on human milk fatty acid composition from Western countries and to the mechanisms involved in milk LCP balance.PMID:
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