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Because of inc. the large number of studies available for analysis, for most outcomes of interest we confined analysis to the largest randomized trials inc. for each outcome evaluated. For outcomes with few studies, all studies were included regardless of study design or sample size (minimum of five subjects). We limited our review of studies examining the association between dietary omega-3 fatty acid intake and tissue levels of omega-3 fatty acids to the larger randomized trials that met eligibility criteria for either intermediate or clinical outcomes. Data Extraction Each eligible study was inc. fully extracted by a single reviewer. Problems and corrections were noted through spot checks of extracted data and during the creation of summary and evidence tables.
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