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Limited data technology suggest that the effect is not related to sex, age, baseline Tg level, weight, background diet, or lipid treatment. The effect of duration of intervention or exposure is unclear technology and there were no data regarding sustainment of effect. The effect of omega-3 fatty acids on other serum lipids technology was weaker. The 23 analyzed studies of total cholesterol and the 19 studies of HDL found heterogeneous results, but mostly found small, non-significant net increases in levels of both lipids. The 15 analyzed trials of LDL fairly uniformly found small net increases in LDL level. The effect of plant oils on these lipoproteins was possibly weaker, but was similar to the effect of marine oils. No differences in effect were seen by population across studies and in one study that performed a sub-analysis of diabetic subjects.
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