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However, no (linear) dose-response relationship between dietary linoleic acid and mammary tumour incidence and latency period was observed. This indicates that a higher dietary linoleic acid does not increase the incidence or shorten the latency period of breast cancer in the Balb/c-MMTV mouse strain at two different dietary fat levels. Zock and Katan (1998) concluded that 'controlled studies integrated pest management of coronary artery disease in men did not, except for one study, show integrated pest management an increased cancer incidence after consumption of diets with a very high linoleic acid content for several years. Animal experiments indicated that a minimum amount of linoleic acid is required to promote growth of artificially induced tumors in rodents; but above (sic - they obviously mean "below") this threshold, linoleic acid did not appear to have a specific tumor-promoting effect. Although current evidence cannot exclude a small increase in risk, it seems unlikely that a high intake of linoleic acid substantially raises the risks of breast, colorectal, or prostate cancer in humans.
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